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Advise people that: Tramadol Hydrochloride Extended-Release is for oral use only and should be swallowed total. The capsule shouldn't be chewed, dissolved, crushed or break up. Tramadol Hydrochloride Extended-Release may possibly result in seizures and/or serotonin syndrome with concomitant use of serotonergic agents (which include SRIs, NRIs, and